MEDICAL EBOOK DOWNLOAD, American Journal of Obstetrics & Gynecology AUGUST 2009, Discontinuation of antihypertensive drug use during the first trimester of pregnancy and the risk of preeclampsia and eclampsia among women with chronic hypertension

 MEDICAL EBOOK DOWNLOAD

American Journal of Obstetrics & Gynecology AUGUST 2009

Discontinuation of antihypertensive drug use during the first trimester of pregnancy and the risk of preeclampsia and eclampsia among women with chronic hypertension

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OBJECTIVE: The goal of this study was to investigate the association
between the discontinuation of antihypertensive medication use during
the first trimester of pregnancy and the risk of preeclampsia and
eclampsia.

STUDY DESIGN: We conducted a nested case-control approach
within a cohort that was reconstructed from the linkage of 3 databases.
To be included in the study, women had to match the following
criteria: (1) between 15-45 years old on the first day of
gestation, (2) covered by Québec’s Drug Insurance Plan for at least
12 months before and during pregnancy, (3) exposed to an antihypertensive
drug on the first day of gestation, and (4) have had a delivery. Multivariate conditional logistic regression models were used to estimate the risk.

RESULTS: Adjusting for confounders, the odds ratio was 0.66; 95%
confidence interval, 0.27-1.56.

CONCLUSION: Our finding does not support the presence of a statistically
significant association between antihypertensive discontinuation
during the first trimester of pregnancy and the risk of
preeclampsia and eclampsia.

Key words: antihypertensive drug discontinuation, chronic
hypertension, eclampsia, preeclampsia, pregnancy